| Player | Comp/Att | Ps-Yards | Ps-TDs | int |
| Murray, Kyler | 26/40 | 230 | 1 | 1 |
|
| Player | Comp/Att | Ps-Yards | Ps-TDs | int |
| Garoppolo, Jimmy | 19/33 | 259 | 2 | 0 |
|
| Player | Att | Yards | ave | TDs |
| Murray, Kyler | 13 | 91 | 7.0 | 1 |
| Drake, Kenyan | 16 | 60 | 3.8 | 1 |
| Edmonds, Chase | 6 | 26 | 4.3 | 0 |
| Streveler, Chris | 1 | 3 | 3.0 | 0 |
|
| Player | Att | Yards | ave | TDs |
| Mostert, Raheem | 15 | 56 | 3.7 | 0 |
| McKinnon, Jerick | 3 | 24 | 8.0 | 0 |
| Coleman, Tevin | 4 | 18 | 4.5 | 0 |
| Garoppolo, Jimmy | 1 | 9 | 9.0 | 0 |
| Kittle, George | 1 | 9 | 9.0 | 0 |
| Juszczyk, Kyle | 1 | 7 | 7.0 | 0 |
|
| Player | T/Rec | Yards | ave | TDs |
| Hopkins, DeAndre | 16/14 | 151 | 10.8 | 0 |
| Fitzgerald, Larry | 5/4 | 34 | 8.5 | 0 |
| Arnold, Dan | 2/2 | 21 | 10.5 | 0 |
| Edmonds, Chase | 5/3 | 19 | 6.3 | 1 |
| Drake, Kenyan | 2/2 | 5 | 2.5 | 0 |
| Kirk, Christian | 5/1 | 0 | 0.0 | 0 |
|
| Player | T/Rec | Yards | ave | TDs |
| Mostert, Raheem | 5/4 | 95 | 23.8 | 1 |
| Kittle, George | 5/4 | 44 | 11.0 | 0 |
| Juszczyk, Kyle | 2/1 | 41 | 41.0 | 0 |
| Bourne, Kendrick | 5/2 | 34 | 17.0 | 0 |
| McKinnon, Jerick | 5/3 | 20 | 6.7 | 1 |
| Reed, Jordan | 2/2 | 12 | 6.0 | 0 |
| Taylor, Trent | 5/2 | 7 | 3.5 | 0 |
| Coleman, Tevin | 2/1 | 6 | 6.0 | 0 |
|
| Player | XP/XA | FG/FGa | 1-39 | 40-49 | 50+ | FSV |
| Gonzalez, Zane | 3/3 | 1/3 | 0/0 | 0/1 | 1/2 | 6 |
|
| Player | XP/XA | FG/FGa | 1-39 | 40-49 | 50+ | FSV |
| Gould, Robbie | 2/2 | 2/2 | 1/1 | 0/0 | 1/1 | 8 |
|
| Player | Fum | F lost | F Rec | F Forc | F TDs |
No Fumbles |
|
| Player | Fum | F lost | F Rec | F Forc | F TDs |
| Alexander, Kwon | 0 | 0 | 0 | 1 | 0 |
| Bosa, Nick | 0 | 0 | 0 | 1 | 0 |
|
| Player | Int | Ret. Yds. | Ret. TDs |
No Interceptions |
|
| Player | Int | Ret. Yds. | Ret. TDs |
| Tartt, Jaquiski | 1 | | 0 |
|
| Player | Tackles | Assists | Sacks |
| Baker, Budda | 10 | 5 | 0 |
| Campbell, De'Vondre | 5 | 2 | 0 |
| Hicks, Jordan | 4 | 2 | 0 |
| Banjo, Chris | 3 | 3 | 0 |
| Simmons, Isaiah | 3 | 0 | 0 |
| Kirkpatrick, Dre | 3 | 0 | 0 |
| Blackson, Angelo | 2 | 0 | 1 |
| Allen, Zach | 2 | 0 | 1 |
| Reddick, Haason | 2 | 1 | 0 |
| Thompson, Jalen | 1 | 0 | 0 |
| Peters, Corey | 1 | 0 | 0 |
| Jones, Chandler | 1 | 1 | 1 |
| Kennard, Devon | 1 | 0 | 0 |
| Murphy Jr., Byron | 0 | 2 | 0 |
|
| Player | Tackles | Assists | Sacks |
| Moseley, Emmanuel | 10 | 5 | 0 |
| Alexander, Kwon | 8 | 2 | 0 |
| Warner, Fred | 5 | 4 | 0 |
| Sherman, Richard | 4 | 0 | 0 |
| Tartt, Jaquiski | 3 | 1 | 0 |
| Bosa, Nick | 3 | 3 | 0 |
| Greenlaw, Dre | 3 | 2 | 0 |
| Hyder Jr., Kerry | 3 | 0 | 1 |
| Williams, K'Waun | 2 | 1 | 0 |
| Ward, Jimmie | 2 | 2 | 0 |
| Ford, Dee | 1 | 2 | 0 |
| Givens, Kevin | 1 | 0 | 0 |
| Jones, D.J. | 1 | 0 | 1 |
| Moore, Tarvarius | 1 | 0 | 0 |
| Witherspoon, Ahkello | 1 | 0 | 0 |
| Kinlaw, Javon | 0 | 1 | 0 |
| Armstead, Arik | 0 | 1 | 0 |
|
|
