| Player | Comp/Att | Ps-Yards | Ps-TDs | int |
| McCoy, Colt | 22/26 | 249 | 1 | 0 |
| Kirk, Christian | 1/1 | 33 | 0 | 0 |
|
| Player | Comp/Att | Ps-Yards | Ps-TDs | int |
| Garoppolo, Jimmy | 28/40 | 326 | 2 | 1 |
|
| Player | Att | Yards | ave | TDs |
| Conner, James | 21 | 96 | 4.6 | 2 |
| Benjamin, Eno | 9 | 39 | 4.3 | 1 |
| McCoy, Colt | 7 | 23 | 3.3 | 0 |
| Edmonds, Chase | 1 | 3 | 3.0 | 0 |
| Streveler, Chris | 1 | 2 | 2.0 | 0 |
|
| Player | Att | Yards | ave | TDs |
| Mitchell, Elijah | 8 | 36 | 4.5 | 0 |
| Garoppolo, Jimmy | 1 | 3 | 3.0 | 0 |
| Hasty, JaMycal | 1 | 2 | 2.0 | 0 |
| Aiyuk, Brandon | 1 | -2 | -2.0 | 0 |
|
| Player | T/Rec | Yards | ave | TDs |
| Kirk, Christian | 6/6 | 91 | 15.2 | 0 |
| Conner, James | 5/5 | 77 | 15.4 | 1 |
| Wesley, Antoine | 3/3 | 62 | 20.7 | 0 |
| Ertz, Zach | 5/3 | 27 | 9.0 | 0 |
| Moore, Rondale | 5/5 | 25 | 5.0 | 0 |
| Daniels, Darrell | 2/1 | 0 | 0.0 | 0 |
|
| Player | T/Rec | Yards | ave | TDs |
| Kittle, George | 8/6 | 101 | 16.8 | 1 |
| Aiyuk, Brandon | 8/6 | 89 | 14.8 | 1 |
| Samuel, Deebo | 9/5 | 63 | 12.6 | 0 |
| Mitchell, Elijah | 5/5 | 43 | 8.6 | 0 |
| Juszczyk, Kyle | 2/2 | 14 | 7.0 | 0 |
| Hasty, JaMycal | 4/3 | 11 | 3.7 | 0 |
| Sanu Sr., Mohamed | 3/1 | 5 | 5.0 | 0 |
|
| Player | XP/XA | FG/FGa | 1-39 | 40-49 | 50+ | FSV |
| Prater, Matt | 4/4 | 1/1 | 1/1 | 0/0 | 0/0 | 7 |
|
| Player | XP/XA | FG/FGa | 1-39 | 40-49 | 50+ | FSV |
| Gould, Robbie | 2/2 | 1/1 | 1/1 | 0/0 | 0/0 | 5 |
|
| Player | Fum | F lost | F Rec | F Forc | F TDs |
| Hicks, Jordan | 0 | 0 | 2 | 0 | 0 |
| Murphy Jr., Byron | 0 | 0 | 0 | 1 | 0 |
| Simmons, Isaiah | 0 | 0 | 0 | 1 | 0 |
|
| Player | Fum | F lost | F Rec | F Forc | F TDs |
| Bosa, Nick | 0 | 0 | 0 | 1 | 0 |
|
| Player | Int | Ret. Yds. | Ret. TDs |
| Baker, Budda | 1 | | 0 |
|
| Player | Int | Ret. Yds. | Ret. TDs |
No Interceptions |
|
| Player | Tackles | Assists | Sacks |
| Simmons, Isaiah | 6 | 0 | 0 |
| Hicks, Jordan | 5 | 3 | 0 |
| Thompson, Jalen | 3 | 3 | 0 |
| Vallejo, Tanner | 3 | 0 | 0 |
| Golden, Markus | 3 | 2 | 3 |
| Baker, Budda | 2 | 5 | 0 |
| Alford, Robert | 1 | 1 | 0 |
| Allen, Zach | 1 | 0 | 0 |
| Jones, Chandler | 1 | 2 | 1 |
| Kennard, Devon | 1 | 0 | 0 |
| Murphy Jr., Byron | 1 | 3 | 0 |
| Phillips, Jordan | 1 | 0 | 1 |
| Gardeck, Dennis | 1 | 0 | 0 |
| Wilson, Marco | 1 | 3 | 0 |
| Mauro, Josh | 0 | 1 | 0 |
| Collins, Zaven | 0 | 2 | 0 |
| Dogbe, Michael | 0 | 1 | 0 |
|
| Player | Tackles | Assists | Sacks |
| Warner, Fred | 5 | 8 | 0 |
| Wilson, Tavon | 5 | 2 | 0 |
| Jones, D.J. | 4 | 4 | 0 |
| Al_Shaair, Azeez | 4 | 5 | 0 |
| Bosa, Nick | 3 | 1 | 0 |
| Moseley, Emmanuel | 3 | 3 | 0 |
| Kirkpatrick, Dre | 3 | 0 | 0 |
| Hufanga, Talanoa | 3 | 1 | 0 |
| Norman, Josh | 2 | 0 | 0 |
| Williams, K'Waun | 2 | 1 | 0 |
| Armstead, Arik | 2 | 8 | 1 |
| Givens, Kevin | 1 | 1 | 0 |
| Ebukam, Samson | 1 | 1 | 0 |
| Key, Arden | 1 | 0 | 1 |
| Willis, Jordan | 1 | 3 | 0 |
| Street, Kentavius | 0 | 1 | 0 |
|
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